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0 · YSL – YSL Lab
1 · YSL Lab
2 · Volume regulation and KCl cotransport in reticulocyte
3 · The KCl cotransporter isoform KCC3 can play an important role in
4 · The KCl cotransporter isoform KCC3 can play an important role
5 · Structures and an activation mechanism of human potassium
6 · Structure and mechanism of the cation–chloride
7 · KCl Cotransport Is an Important Modulator of Human
8 · Cryo

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The electroneutral K + -Cl − cotransporters (KCCs) play fundamental roles in trans-epithelial transport, cell volume regulation, and neuronal excitability. 1 The neuronal .We would like to show you a description here but the site won’t allow us.

Two major research projects in the YSL Group are (1) to understand and design cyclic peptides with desired conformations to modulate protein–protein interactions and (2) to elucidate the .

Abstract. Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles .Abstract. Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume . The KCl cotransporter (KCC) has been implicated not only in regulatory volume decrease but also in transepithelial salt absorption, renal K + secretion, myocardial K + loss .

YSL – YSL Lab. Yu-Shan Lin. Professor and Department Chair of Chemistry Tufts University 62 Talbot Avenue Pearson-103X Medford, MA 02155 Tel: 617-627-3689 E-mail: yu .

KCC2, a neuronal-specific isoform, can lower intracellular Cl (-) and is critical for inhibitory GABA responses in the mature central nervous system. KCC3, initially cloned from .

After KCC activation in vitro by cell swelling using the nystatin method, the initial changes in reticulocyte MCV and CHC with time were used to estimate flux rates mediated by .Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and .

Abstract. Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell . The electroneutral K + -Cl − cotransporters (KCCs) play fundamental roles in trans-epithelial transport, cell volume regulation, and neuronal excitability. 1 The neuronal-specific KCC2 (SLC12A5). Abstract. Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume,.Two major research projects in the YSL Group are (1) to understand and design cyclic peptides with desired conformations to modulate protein–protein interactions and (2) to elucidate the structural and functional roles of post-translational modifications and .

YSL – YSL Lab

The KCl cotransporter (KCC) has been implicated not only in regulatory volume decrease but also in transepithelial salt absorption, renal K + secretion, myocardial K + loss during ischemia, and regulation of neuronal Cl − concentrations (1–3). A major advance in the understanding of KCC has been the recent identification of genes that .

YSL Lab

KCC2, a neuronal-specific isoform, can lower intracellular Cl (-) and is critical for inhibitory GABA responses in the mature central nervous system. KCC3, initially cloned from vascular endothelial cells, is widely but not universally distributed and has an unknown physiological significance.Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. After KCC activation in vitro by cell swelling using the nystatin method, the initial changes in reticulocyte MCV and CHC with time were used to estimate flux rates mediated by KCC, assuming that changes were associated with isotonic KCl movements. Abstract. Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume regulation, auditory system function, and γ-aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission.

The structure of the potassium-chloride cotransporter KCC4 provides insight into the basis of ion specificity, transport stoichiometry, and activity regulation for a broadly physiologically and clinically important transporter family.

YSL – YSL Lab. Yu-Shan Lin. Professor and Department Chair of Chemistry Tufts University 62 Talbot Avenue Pearson-103X Medford, MA 02155 Tel: 617-627-3689 E-mail: [email protected] Curriculum Vitae. ORCID 0000-0001-6460-2877. The electroneutral K + -Cl − cotransporters (KCCs) play fundamental roles in trans-epithelial transport, cell volume regulation, and neuronal excitability. 1 The neuronal-specific KCC2 (SLC12A5).

Abstract. Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume,.

Two major research projects in the YSL Group are (1) to understand and design cyclic peptides with desired conformations to modulate protein–protein interactions and (2) to elucidate the structural and functional roles of post-translational modifications and . The KCl cotransporter (KCC) has been implicated not only in regulatory volume decrease but also in transepithelial salt absorption, renal K + secretion, myocardial K + loss during ischemia, and regulation of neuronal Cl − concentrations (1–3). A major advance in the understanding of KCC has been the recent identification of genes that . KCC2, a neuronal-specific isoform, can lower intracellular Cl (-) and is critical for inhibitory GABA responses in the mature central nervous system. KCC3, initially cloned from vascular endothelial cells, is widely but not universally distributed and has an unknown physiological significance.

Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. After KCC activation in vitro by cell swelling using the nystatin method, the initial changes in reticulocyte MCV and CHC with time were used to estimate flux rates mediated by KCC, assuming that changes were associated with isotonic KCl movements.

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YSL – YSL Lab

Abstract. Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume regulation, auditory system function, and γ-aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission.

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The structure of the potassium-chloride cotransporter KCC4 provides insight into the basis of ion specificity, transport stoichiometry, and activity regulation for a broadly physiologically and clinically important transporter family.

Volume regulation and KCl cotransport in reticulocyte

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